NORMAN N. KOHN, M.D.; ROBERT E. HUGHES, PH.D.; DANIEL J. MCCARTY JR., M.D.; JAMES S. FAIRES, M.D.
In the course of examining over 200 consecutive specimens of synovial fluid with phase contrast and polarized light microscopy, a collection of fluids from seven patients was obtained containing significant amounts of an unknown crystalline material. Since crystalline urates had previously been identified from the joint fluids of patients with acute and chronic gout it was initially thought that some of these patients had this disorder. With increased experience with this group, however, it became evident that such was not the case: There were significant differences clinically between the gouty patients and the group under discussion; the serum urate levels
KOHN NN, HUGHES RE, MCCARTY DJ, FAIRES JS. The Significance of Calcium Phosphate Crystals in the Synovial Fluid of Arthritic Patients: The "Pseudogout Syndrome": II. Identification of Crystals. Ann Intern Med. ;56:738–745. doi: 10.7326/0003-4819-56-5-738
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Published: Ann Intern Med. 1962;56(5_Part_1):738-745.
Hospital Medicine, Rheumatology.
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