M. LERTZMAN, M.D.; L. G. ISRAELS, M.D., F.R.C.P. (C); R. M. CHERNIACK, M.D., F.R.C.P. (C), F.A.C.P.
Chronic exposure to high altitude leads to the development of secondary polycythemia which is roughly proportional to the degree of hypoxia (1, 2). The hematopoietic response to altitude hypoxia has been further delineated by measurement of the rate of movement of radioactive iron out of the plasma and its subsequent incorporation in the red blood cells (3).
Although patients who are hypoxic because of cardiorespiratory disease also develop secondary polycythemia, it has been suggested that many patients with pulmonary emphysema do not respond normally to the hypoxic stimulus (4, 5). It was of interest, therefore, to study the ferrokinetic and
LERTZMAN M, ISRAELS LG, CHERNIACK RM. Erythropoiesis and Ferrokinetics in Chronic Respiratory Disease. Ann Intern Med. ;56:821–833. doi: 10.7326/0003-4819-56-6-821
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Published: Ann Intern Med. 1962;56(6):821-833.
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