FRED Q. VROOM, M.D.; RICHARD E. BROWN, M.D.; HUGH DEMPSEY, M.D.; S. RICHARDSON HILL JR., M.D., F.A.C.P.
In recent years, clinicians, as well as biochemists, have been intrigued by the synthesis, excretion, and metabolic effects of substances produced by neoplastic tumors, particularly tumors arising from chromaffin cells of the sympathetic nervous system.
Pheochromocytomata, arising from the chromaffin tissue of the adrenal medulla and associated with disturbances in the metabolism of phenylalanine, have been widely investigated, and a relatively successful diagnostic and therapeutic approach now has been delineated for these tumors. Less well understood and of considerable current clinical interest are the chromaffin cell neoplasms of the gastrointestinal tract (1), designated as malignant carcinoid tumors. An abnormality of
VROOM FQ, BROWN RE, DEMPSEY H, HILL SR. Studies on Several Possible Antiserotonin Compounds in a Patient with the Functioning Carcinoid Syndrome. Ann Intern Med. ;56:941–945. doi: 10.7326/0003-4819-56-6-941
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Published: Ann Intern Med. 1962;56(6):941-945.
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