MARTIN L. LEE, M.D.; GIOVANNI RACCUGLIA, M.D.
Blood clotting defects which first become manifest in advanced age and in absence of family history should be evaluated not only for quantitative deficiencies but also for qualitative derangements of the normal blood coagulation mechanism. Those disturbances of the coagulation mechanism which are not associated with deficiency are often said to be caused by "circulating anticoagulants" (1, 2). The mechanism of action of these "anticoagulants" has been ascribed to specific chemical (3) or immunological (4) inhibition of certain coagulation factors, to complexing of abnormal proteins with coagulation factors (5), or to "interference" of the extraneous substance with the coagulation reactions
LEE ML, RACCUGLIA G. Acquired Inhibitor of Blood Coagulation. Ann Intern Med. ;56:946–956. doi: 10.7326/0003-4819-56-6-946
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Published: Ann Intern Med. 1962;56(6):946-956.
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