VICTOR A. MCKUSICK, M.D., F.A.C.P.
Several factors have combined to make the X chromosome of man an object of particular research interest recently and currently (1). The leading factor is, undoubtedly, the cytologic advances which have permitted study of the X chromosome in sex anomalies. The origin and functional significance of the Barr body ("sex chromatin") have been questions for investigation. Discovery of an X-linked blood group has provided a valuable addition to the technical armamentarium for mapping the X chromosome. An hypothesis suggested by Mary Lyon, among others, has stimulated much inquiry into certain functional aspects of the X chromosome.
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MCKUSICK VA. On the X Chromosome of Man. Ann Intern Med. 1962;56:991–996. doi: 10.7326/0003-4819-56-6-991
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Published: Ann Intern Med. 1962;56(6):991-996.
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