F. ROBERT FEKETY JR., M.D.; PHILIP S. NORMAN, M.D.; LEIGHTON E. CLUFF, M.D.
Septicemia and chronic urinary tract infections caused by Gram-negative bacilli rarely respond dramatically to antibacterial therapy. There are several reasons for this. First, and perhaps of paramount importance, is the clinical setting of impaired local or systemic resistance in which these infections usually occur. The appearance of infection in such patients is a signal that defense mechanisms vital to the control of organisms with little pathogenicity have been tested and found wanting. In these circumstances, only highly effective counter-measures will lead to a bactriologic cure. A second factor, then, is the relative insensitivity of these organisms to the commonly employed
FEKETY FR, NORMAN PS, CLUFF LE. The Treatment of Gram-negative Bacillary Infections with Colistin: The Toxicity and Efficacy of Large Doses in Forty-eight Patients. Ann Intern Med. ;57:214–229. doi: 10.7326/0003-4819-57-2-214
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Published: Ann Intern Med. 1962;57(2_Part_1):214-229.
Emergency Medicine, Infectious Disease.
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