HAROLD J. SIMON, M.D., PH.D.; LOWELL A. RANTZ, M.D., F.A.C.P.
The introduction of penicillin revolutionized the treatment of Gram-positive coccal infections. Mortality from pneumococcal and beta hemolytic streptococcal infections became a rarity. Staphylococcal infections also responded to penicillin therapy with almost uniform regularity initially, but the incidence of penicillin resistant infections began to rise even before 1950. As many as 90 per cent of staphylococcal infections seen in hospital settings were associated with penicillin resistant strains by the mid-1950's (1). Treatment was based on combinations of bacteriostatic drugs or on the use of toxic agents which were difficult to administer (2).
Treatment failures were not always due to antimicrobial resistance
SIMON HJ, RANTZ LA. The Newer Penicillins: II. Clinical Experiences with Methicillin and Oxacillin. Ann Intern Med. ;57:344–362. doi: 10.7326/0003-4819-57-3-344
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Published: Ann Intern Med. 1962;57(3):344-362.
Infectious Disease, Rheumatology.
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