WARREN D. BOWMAN JR., M.D.
Although Rath and Finch introduced the technique of staining bone marrow preparations for iron over a decade ago (1), this simple and useful procedure has not yet found wide application. The significance of the presence or absence of stainable iron, or hemosiderin, in marrow particles and normoblasts has been discussed elsewhere (2-6) and will be reviewed briefly below. The purpose of this paper is to illustrate the use of the Prussian blue reaction for hemosiderin in solving diagnostic problems commonly encountered by the internist, pathologist, and hematologist.
Marrow is aspirated in the usual manner from the sternum,
BOWMAN WD. Use of the Prussian Blue Reaction in the Differential Diagnosis of Anemias. Ann Intern Med. ;57:412–418. doi: 10.7326/0003-4819-57-3-412
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Published: Ann Intern Med. 1962;57(3):412-418.
Hematology/Oncology, Red Cell Disorders.
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