H. MITCHELL PERRY JR., M.D.
During the last decade, effective antihypertensive drugs were widely used for the first time. The decreased mortality from severe hypertension (1-4) was expected, but the variety and frequency of associated toxic phenomena were surprising. Each of the first 2 effective drugs was associated with its own unprecedented toxic syndrome. Toxicity from hydralazine simulated rheumatoid arthritis and disseminated lupus erythematosus (5). Hexamethonium produced fatal fibrinous pneumonitis (6). Less catastrophic, but nonetheless impressive neurologic abnormalities, including a characteristic coarse tremor, followed the ingestion of the secondary amine ganglionoplegic agent, mecamylamine (7). The use of milder antihypertensive drugs has evoked less serious and
PERRY HM. Multiple Reactions to Antihypertensive Agents during Treatment of Malignant Hypertension. Ann Intern Med. ;57:441–450. doi: 10.7326/0003-4819-57-3-441
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Published: Ann Intern Med. 1962;57(3):441-450.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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