JOSEPH J. BUNIM, M.D., F.A.C.P.; ROBERT S. KROOTH, M.D.; ARNOLD WEINBERG, M.D.; R. RODNEY HOWELL, M.D.; BERT N. LA DU, M.D.; J. E. SEEGMILLER, M.D.
Dr. Joseph J. Bunim: In a recent Harvey lecture (1), Dr. James V. Neel stated that "The ultimate basis of biogenetic traits resides in some 20 thousand pairs of genes. The term gene refers to that functional subdivision of chromosomes which conveys a unit biochemical message." To be able to intercept this message and to interpret it in precise biochemical language by means of growing human cell lines in tissue culture and by quantitatively analyzing their enzymatic contents, is a breakthrough in human genetics of considerable magnitude and even greater promise.
Soon after Dr. Robert Krooth came to the National
JOSEPH J. BUNIM, ROBERT S. KROOTH, ARNOLD WEINBERG, R. RODNEY HOWELL, BERT N. LA DU, J. E. SEEGMILLER. Biochemical Abnormalities in Hereditary Diseases. Ann Intern Med. 1962;57:472–497. doi: 10.7326/0003-4819-57-3-472
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Published: Ann Intern Med. 1962;57(3):472-497.
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