WESLEY W. SPINK, M.D., F.A.C.P.
Since world war II extensive investigations on shock have been carried out. Within the past 5 years the subject has been thoroughly reviewed in 3 symposia (1-3). These discussions have emphasized the complexity of the problem and the necessity for more precise information on the nature of shock in the human being.
Although hypotension is a cardinal sign in the early stages of shock, a more fundamental concept is necessary in defining the condition. Shock is the inadequate perfusion of tissues and organs with oxygenated blood resulting in hemodynamic changes and metabolic alterations that may be irreversible. Shock can be
SPINK WW. Endotoxin Shock. Ann Intern Med. ;57:538–552. doi: 10.7326/0003-4819-57-4-538
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Published: Ann Intern Med. 1962;57(4):538-552.
Cardiology, Education and Training, Hematology/Oncology, Hospital Medicine, Infectious Disease.
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