MORRIS J. SEIDE, M.D.
Since their introduction into clinical medicine 20 years ago (1), coumarin drugs have become widely used. In the past 10 years, the number of patients maintained on long-term therapy has increased phenomenally. In the Hartford area, the clinical laboratories now perform about 500, and the hospital laboratories about 1,200 prothrombin tests each week, serving a population of about 350,000.
The prothrombin test devised some 25 years ago by Quick (2) is widely used by clinicians as a guide to the dose of coumarin drug to be prescribed. This test is a bio-assay which requires meticulous technique, experienced technicians, and reliable
SEIDE MJ. Laboratory Control of Coumarin Therapy: The Clinician's Dilemma. Ann Intern Med. ;57:572–581. doi: 10.7326/0003-4819-57-4-572
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Published: Ann Intern Med. 1962;57(4):572-581.
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