JOHN H. FRENSTER, M.D.
The steady development of increasingly sensitive techniques for the study of human structure and function has created new opportunities and new dilemmas in the diagnosis of disease (1).
Disease may now be studied earlier in its course (2), or it may even be predicted before its onset (3). Objective evidence of the efficacy of therapy can be obtained by appropriate studies before and after treatment (4). The prospect exists of determining not only the presence, but also the magnitude, of a specific disease in a given subject (5). However, as techniques become more sensitive and disease is detected earlier, or
FRENSTER JH. Load Tolerance as a Quantitative Estimate of Health. Ann Intern Med. ;57:788–794. doi: 10.7326/0003-4819-57-5-788
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Published: Ann Intern Med. 1962;57(5):788-794.
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