HAROLD O. CONN, M.D.; DONALD J. DALESSIO, M.D.
Hemorrhage from esophageal varices is one of the most formidable emergencies in medicine. Despite the use of blood transfusions, esophageal tamponade, and emergency surgical procedures, more than half the patients who bleed from esophageal varices die of exsanguination or the sequelae of the hemorrhage (1-5).
The recent demonstration by Kehne, Hughes, and Gompertz that posterior pituitary extract (Pituitrin) can control bleeding from esophageal varices by reducing the portal venous pressure has aroused great interest (6). Its efficacy in controlling hemorrhage from esophageal varices has been confirmed by the clinical evaluations of Schwartz (7), Shaldon (8), and Merigan (9) and their
CONN HO, DALESSIO DJ. Multiple Infusions of Posterior Pituitary Extract in the Treatment of Bleeding Esophageal Varices. Ann Intern Med. ;57:804–809. doi: 10.7326/0003-4819-57-5-804
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Published: Ann Intern Med. 1962;57(5):804-809.
Endocrine and Metabolism, Gastroenterology/Hepatology, Neurology, Pituitary Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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