THOMAS W. SHEEHY, M.D., F.A.C.P.; BARBARA BAGGS, B.S., M.A.; ENRIQUE PEREZ-SANTIAGO, M.D.; MARTIN H. FLOCH, M.D.
Untreated tropical sprue is a chronic unrelenting disease characterized by diarrhea, weight loss, weakness, and eventually by severe anemia and emaciation. Without therapy, frequent relapses occur and the disease may terminate in invalidism or death from inanition, intercurrent disease, or a semi-choleraic attack (1, 2). The advent of liver therapy and, later, of folic acid altered this grim prognosis and provided a therapeutic means of returning most patients with tropical sprue to gainful activity. Indeed, the remarkable effect of folic acid or vitamin B12 therapy and, in some cases, of broad spectrum antibiotics led some to consider the disease to
SHEEHY TW, BAGGS B, PEREZ-SANTIAGO E, FLOCH MH. Prognosis of Tropical Sprue: A Study of the Effect of Folic Acid on the Intestinal Aspects of Acute and Chronic Sprue. Ann Intern Med. ;57:892–908. doi: 10.7326/0003-4819-57-6-892
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Published: Ann Intern Med. 1962;57(6):892-908.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology.
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