JULES STAHL, M.D., F.A.C.P. (HON.)
Studies on blood ammonia have a long experimental and biochemical record going back to the work of the Pavlov school on meat intoxication in dogs with Eck fistulas (1, 2). Later studies, using more satisfactory methods, were applied to the investigation of liver disease for the first time by Burchi in 1927 (3), by Van Caulaert and Deviller in their extensive studies in Strasbourg in 1932 (4), and by Esben Kirk in 1935 (5).
Van Caulaert and Esben Kirk had noticed in cirrhotic subjects temporary elevation of the venous blood ammonia after an oral test dose of ammonium salts. They
STAHL J. Studies of the Blood Ammonia in Liver Disease: Its Diagnostic, Prognostic, and Therapeutic Significance. Ann Intern Med. ;58:1–24. doi: 10.7326/0003-4819-58-1-1
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Published: Ann Intern Med. 1963;58(1):1-24.
Gastroenterology/Hepatology, Liver Disease.
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