MARVIN TURCK, M.D.; ROBERT I. LINDEMEYER, M.D.; ROBERT G. PETERSDORF, M.D.
Serious infections with Gram-negative pathogens have become an increasingly important problem in medical practice, particularly in debilitated hospitalized patients (1, 2). For example, at King County Hospital during the years 1960-61, the over-all incidence of Gram-negative bacteremia was greater than the combined incidence of bacteremia associated with the pneumococcus, staphylococcus, and streptococcus. The response of Gram-negative infections to antimicrobial therapy frequently has been unsatisfactory. While the outcome of these infections is often determined primarily by the patients' underlying disease rather than by the therapeutic regimen, antimicrobials remain the cornerstone of therapy. Therefore, a practical method of determining antimicrobial susceptibility of
TURCK M, LINDEMEYER RI, PETERSDORF RG. Comparison of Single-disc and Tube-dilution Techniques in Determining Antibiotic Sensitivities of Gram-negative Pathogens. Ann Intern Med. ;58:56–65. doi: 10.7326/0003-4819-58-1-56
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Published: Ann Intern Med. 1963;58(1):56-65.
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