KENNETH M. LLOYD II, M.D.; MACEY DENNIS, M.D.
In recent years an accelerated interest has been directed toward a better understanding of the rare, familial, developmental diseases. The purpose of this communication is to define an unusual symptom complex which previously has not been described. Because of the multiplicity of findings, and the ill-defined classification for this disease, it shall be referred to as "Cowden's disease," the family name of the propositus. The clinical findings include: an adenoid facies; hypoplasia of the mandible and maxilla; a high-arch palate; hypoplasia of the soft palate and uvula; microstomia; papillomatosis of the lips and oral pharynx; scrotal tongue; multiple thyroid adenomas;
LLOYD KM, DENNIS M. Cowden's Disease: A Possible New Symptom Complex with Multiple System Involvement. Ann Intern Med. ;58:136–142. doi: 10.7326/0003-4819-58-1-136
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Published: Ann Intern Med. 1963;58(1):136-142.
Gastroenterology/Hepatology, Hematology/Oncology, Hospital Medicine, Liver Disease.
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