HUGH FUDENBERG, M.D.; E. C. FRANKLIN, M.D.
The existence of genetically determined differences in certain serum proteins, comparable to genetic variations in blood type, eye color, and other hereditary traits, has become apparent in recent years. Evidence of such intraspecies heterogeneity was provided by the observations of Cumley and Irwin in 1942 (1) and confirmed by Thompson, Foster, Gowen, and Tauber in 1954 (2). In the past 5 years, hereditary differences in several groups of proteins in normal human serum have been definitely delineated. Different types of haptoglobin and of transferrin, for example, can be readily detected by dissimilarities in their electrophoretic behavior in starch gel (3-5).
FUDENBERG H, FRANKLIN EC. Human Gamma Globulin: Genetic Control and Its Relation to Disease. Ann Intern Med. 1963;58:171–180. doi: 10.7326/0003-4819-58-1-171
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Published: Ann Intern Med. 1963;58(1):171-180.
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