ROBERT I. LINDEMEYER, M.D.; MARVIN TURCK, M.D.; ROBERT G. PETERSDORF, M.D., F.A.C.P.
The treatment of urinary tract infections has been generally unsatisfactory, and the long histories of repeated instrumentation and multiple courses of antimicrobial therapy interspersed with flare-ups characterized by classical symptoms of "cystitis" or "pyelonephritis" offered by these patients attest to the refractoriness of these infections. Why infections of the urinary tract have been so notoriously resistant to attack with both medical and surgical therapeutic maneuvers is not entirely clear. Among the possible reasons are: failure to remedy obstruction to urine flow; emergence of antibiotic resistant mutants during or after treatment; presence of "mixed infections" in which only the sensitive pathogens
ROBERT I. LINDEMEYER, MARVIN TURCK, ROBERT G. PETERSDORF. Factors Determining the Outcome of Chemotherapy in Infections of the Urinary Tract. Ann Intern Med. 1963;58:201–216. doi: 10.7326/0003-4819-58-2-201
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Published: Ann Intern Med. 1963;58(2):201-216.
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