MARK L. ARMSTRONG, M.D.; ANNETTE E. FITZ, M.D.; LOUIS SCHWARTZ, M.D.
A case of metabolic alkalosis that occurred in association with idiopathic malignant hypertension and disappeared after antihypertensive drug therapy is reported.
Hypertensive disease per se has no connotation of electrolyte or acid-base disturbance. Even in the malignant phase of hypertension, electrolyte balance is usually normal (1), or only mildly changed (2), before renal insufficiency or congestive heart failure occurs. However, aldosterone excretion tends to increase throughout all levels of hypertension (3-5), and may increase remarkably in malignant hypertension (2). Against such a background, evidence (6-8) suggests that distinct alkalosis occasionally arises as a metabolic concomitant of hypertension.
ARMSTRONG ML, FITZ AE, SCHWARTZ L. The Response of Metabolic Alkalosis in Severe Hypertension to Antihypertensive Drugs. Ann Intern Med. 1963;58:336–340. doi: 10.7326/0003-4819-58-2-336
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Published: Ann Intern Med. 1963;58(2):336-340.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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