EDWARD C. ATWATER, M.D.; RALPH F. JACOX, M.D., F.A.C.P.
In recent years it has been demonstrated that macroglobulins exist in the sera of most patients with rheumatoid arthritis. One technique for demonstrating this depends on the ability of these macroglobulins to agglutinate 7S gamma globulin. The latex-fixation test is an application of this process. Using this test, several investigators have reported agglutinating factors in the sera of patients with diseases other than rheumatoid arthritis, such as sarcoidosis, syphilis, pulmonary fibrosis, acute viral illnesses, and liver disease (1-9).
A study of the latex-fixation reaction in the sera of 165 patients with various disturbances of hepatic function and morphology is presented
ATWATER EC, JACOX RF. The Latex-fixation Test in Patients with Liver Disease. Ann Intern Med. ;58:419–425. doi: 10.7326/0003-4819-58-3-419
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Published: Ann Intern Med. 1963;58(3):419-425.
Gastroenterology/Hepatology, Liver Disease.
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