MELVIN A. AMUNDSEN, M.D.; JOHN A. SPITTELL JR., M.D.; JOHN H. THOMPSON JR., PH.D.; CHARLES A. OWEN JR., M.D.
The increased incidence of venous thrombo-embolism associated with malignant (1, 2) disease and with the postoperative state (3, 4) is well recognized. Although thrombophlebitis may occur in association with any malignant lesion, it is seen more frequently with cancer of certain organs, especially the pancreas, lung, stomach, and ovary (5-8). Investigation of the changes in the mechanism of blood coagulation in patients with cancer has been relatively neglected compared to the extensive investigations of the changes that follow operation (9-13) or are associated with occlusive arterial disease (14-19).
The evidence for hypercoagulability in patients during the postsurgical period most consistently
AMUNDSEN MA, SPITTELL JA, THOMPSON JH, OWEN CA. Hypercoagulability Associated with Malignant Disease and with the Postoperative State: Evidence for Elevated Levels of Antihemophilic Globulin. Ann Intern Med. 1963;58:608–616. doi: 10.7326/0003-4819-58-4-608
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Published: Ann Intern Med. 1963;58(4):608-616.
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