ROBERT G. SIEKERT, M.D., F.A.C.P.; JACK P. WHISNANT, M.D.; CLARK H. MILLIKAN, M.D., F.A.C.P
The therapy of patients with focal ischemic cerebrovascular disease continues to be a challenge. Each regimen must be considered carefully in regard to its immediate therapeutic effect, its long-term prophylactic effect, and any risks attendant on its use. Meaningful comparisons between treated and untreated patients are extremely difficult to make. It is essential in any study that the investigator defines carefully the patients analyzed and the larger group from which they were selected, and takes into account variations in the natural course of the disease. The present report concerns our experience to date with anticoagulant and surgical therapy.
ROBERT G. SIEKERT, JACK P. WHISNANT, CLARK H. MILLIKAN. Surgical and Anticoagulant Therapy of Occlusive Cerebrovascular Disease. Ann Intern Med. 1963;58:637–641. doi: 10.7326/0003-4819-58-4-637
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Published: Ann Intern Med. 1963;58(4):637-641.
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