L. S. Dreifus, M.D., F.A.C.P.; Y. Watanabe, M.D.; V. Satinsky, M.D.; W. Likoff, M.D., F.A.C.P.
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A satisfactory theory of ventricular fibrillation must explain; (1) initiation of a premature systole and a series of re-entrant waves, and (2) the factors engendering their transformation into fibrillation.
Ten dogs were placed under hypothermia with the aid of cardiopulmonary bypass. Transmembrane potentials, utilizing 2 microelectrodes, and a surface electrogram were recorded simultaneously. Ventricular fibrillation was produced spontaneously by focal heating. Continuous recordings during the transition from a normal action potential to fibrillation potentials showed the following sequence of events: 1. Fibrillation is preceded by one or more ventricular premature systoles with a slow rate of depolarization and incomplete propagation.
Dreifus LS, Watanabe Y, Satinsky V, Likoff W. Electrophysiologic Observations Concerning the Genesis of Ventricular Fibrillation.. Ann Intern Med. ;58:712. doi: 10.7326/0003-4819-58-4-712_1
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Published: Ann Intern Med. 1963;58(4):712.
Cardiology, Rhythm Disorders and Devices.
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