I. H. Scheinberg, M.D.; C. J. A. van den Hamer, Ph.D.; A. G. Morell, M.S.; J. Windsor, B.S.
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In normal healthy adults each milliliter of serum contains close to 1 μg of copper. Almost all of this is present as an integral part of the molecule of ceruloplasmin, a copper-protein of serum. There is a small portion, about a tenth, of the total serum copper that is not part of ceruloplasmin and that is probably loosely bound to albumin.
A precise and accurate determination of the non-ceruloplasmin copper of serum is difficult, since it represents the relatively small difference between total serum copper and ceruloplasmin-copper. We have attempted to analyze, for copper, the supernatant portion of samples of
Scheinberg IH, van den Hamer CJA, Morell AG, Windsor J. The States of Copper in Serum.. Ann Intern Med. ;58:719. doi: 10.7326/0003-4819-58-4-719_1
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Published: Ann Intern Med. 1963;58(4):719.
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