D. H. Mintz, M.D.; M. M. Martin, M.D.; J. J. Canary, M.D.; D. Hellman, M.D.
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Hyperthyroroism is known to increase 24-hour urinary 17-hydroxycortico-steroid (17OHCS) as well as inorganic phosphate excretion. The observation that forenoon phosphate clearance, in contrast, was reduced in hyperthyroidism prompted a study of the circadian variation in serum and urinary inorganic phosphate, and plasma and urinary 17OHCS.
Hyperthyroidism, by accelerating steroid degradation and excretion, lowers plasma free 17OHCS and exaggerates the rhythm in plasma conjugated and total urinary 17OHCS. The lack of significant variation in cortisol half-life and minimal differences in adrenal stimulation by exogenous ACTH at different times throughout 24 hours appear to exclude changes in adrenal responsiveness or peripheral steroid
Mintz DH, Martin MM, Canary JJ, Hellman D. Biologic Rhythms in Hyperthyroidism.. Ann Intern Med. 1963;58:719. doi: 10.7326/0003-4819-58-4-719_2
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Published: Ann Intern Med. 1963;58(4):719.
Endocrine and Metabolism, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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