H. E. Holling, M.D.
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A brother and 2 sisters, known from childhood to have had glycogen storage disease of the liver (Von Gierke's disease), survived to adult life. The course of their disorder was followed. The brother and one sister developed hyperuricemia and symptoms of gout and died from the effects of chronic renal disease at the ages of 40 and 36. The second sister remains healthy and active at the time of this account.
Study of these patients and other reported cases indicates that there may be more than a chance association between gout and glycogen storage disease of the liver. Evidence from
Holling HE. Gout and Glycogen Storage Disease.. Ann Intern Med. ;58:719–720. doi: 10.7326/0003-4819-58-4-719_4
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Published: Ann Intern Med. 1963;58(4):719-720.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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