E. M. Gold, M.D.
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ACTH is now detectable in peripheral human plasma at concentrations as low as 0.5 mU/ 100 ml, utilizing sensitive bioassay techniques currently available. Normal resting levels of ACTH in man range from less than 0.5 to 1.2 mU/100 ml at plasma corticosteroid (PSC) concentrations of 10 to 20 μg/100 ml. Acute myocardial infarction and hypoglycemia, while associated with three- to sixfold increases in PSC, produce little change in plasma ACTH. Only slight rises in circulating ACTH titers, amounting to less than 0.5 mU/100 ml, apparently suffice to elevate PSC levels markedly. The lowest rate of pituitary ACTH secretion required to
E. M. Gold. Kinetics of Pituitary ACTH Secretion in Man.. Ann Intern Med. 1963;58:721. doi: 10.7326/0003-4819-58-4-721_2
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Published: Ann Intern Med. 1963;58(4):721.
Endocrine and Metabolism, Neurology, Pituitary Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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