A. Sjoerdsma, M.D., Ph.D.
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It is well known that pheochromocytomas secrete A excess amounts of the catecholamines, norepinephrine and epinephrine. While diagnosis can usually be made by proper interpretation of the clinical picture and results of pharmacologic tests, chemical assay of the urine for catecholamines and their metabolites affords the most definitive diagnostic evidence and may also offer information on localization of the tumor. Recently, it has been shown that other sympatho-adrenal tumors, i.e., neuroblastoma and ganglioneuroma also may secrete catecholamine intermediates and metabolites. Studies in patients with these various conditions will be used to illustrate the biochemistry of the catecholamines; the diagnostic aspects
Sjoerdsma A. Chemical Diagnosis of Sympath-adrenal Tumors.. Ann Intern Med. ;58:722. doi: 10.7326/0003-4819-58-4-722_1
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Published: Ann Intern Med. 1963;58(4):722.
Adrenal Disorders, Endocrine and Metabolism, Hematology/Oncology.
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