T. T. Puck, Ph.D.
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Recent developments in tissue culture techniques for mammalian somatic cells have introduced revolutionary new advances in human genetics. Application of these techniques to human chromosomal analysis has established that more than one-half per cent of all human live births are accompanied by gross chromosomal abnormalities. All of these produce deep-seated disease, and many involve mental deficiency. The most common types of aberrations are errors in chromosome number, due to non-disjunction, and errors in chromosomal structure, usually due to chromosome breakage which is followed by an abnormal reunion. Most of the anomalies produced are limited to about 5 of the chromosome
Puck TT. Genetic Studies on Somatic Mammalian Cells.. Ann Intern Med. ;58:734. doi: 10.7326/0003-4819-58-4-734_3
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Published: Ann Intern Med. 1963;58(4):734.
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