C. Ezrin, M.D.; L. W. Loach, M.D.; S. Neiman, M.D.; M. Barkin, M.D.; T. F. Nicholson, M.B.
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A reversed diurnal excretory rhythm of water, creatinine, and electrolytes was observed in a woman with fluid retention that first appeared after a head injury. Synthetic oxytocin produced a diuresis and restored a normal excretory rhythm. Recumbency for 24 hours also induced a return to normal rhythm. Spontaneous resumption of a normal cycle of renal excretion, even when the patient continued to be up and about during the day, was sometimes observed 1 day before menstruation.
Inulin, PAH, and endogenous creatinine clearance studies showed that oxytocin and recumbency increased the daytime GFR (glomerular filtration rate). In the isolated, perfused dog
C. Ezrin, L. W. Loach, S. Neiman, M. Barkin, T. F. Nicholson. Is Oxytocin the Diurnal Regulator of Renal Hemodynamics?. Ann Intern Med. 1963;58:742. doi: 10.7326/0003-4819-58-4-742_1
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Published: Ann Intern Med. 1963;58(4):742.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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