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Dr Grette describes in his monograph studies dealing with the effects of a commercially prepared bovine thrombin upon isolated pig platelets. Thrombin initiates a release from "intact" platelets of 5-hydroxytryptamine (serotonin) and the adenine nucleotides AMP, ADP, and ATP. In an attempt to identify the substrate for thrombin, platelet fibrinogen and platelet contractile protein were isolated and examined in some detail. The experiments suggest that both proteins are intracellular and that neither is the substrate for the initial thrombin effect. The release reaction can be broken down into 2 or more steps by substituting trypsin for thrombin or by employing
Studies on the Mechanism of Thrombin-catalyzed Hemostatic Reactions in Blood Platelets.. Ann Intern Med. ;58:752–753. doi: 10.7326/0003-4819-58-4-752_2
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Published: Ann Intern Med. 1963;58(4):752-753.
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