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The disposal or biotransformation of drugs and foreign substances in the human organism is a complex process comprising absorption, conjugation, excretion, and other biologic mechanisms. Many different enzymes are involved in these reactions. Modern work in genetics indicates that enzymes, as all other proteins, are formed under the control of genes. Genetic mutations, therefore, may affect enzymes concerned with drug disposal, and altering enzyme activity may change the biotransformation of a drug. Variation in drug response as well as drug reactions on initial administration of a drug may therefore be sometimes related to genetic differences between individuals. The field of
Pharmacogenetics. Heredity and the Response to Drugs.. Ann Intern Med. ;58:757. doi: 10.7326/0003-4819-58-4-757
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Published: Ann Intern Med. 1963;58(4):757.
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