JOSEPH L. GRANT, M.D., F.A.C.P.; BARRY SMITH, M.D.
For many years bone marrow anoxia was thought to stimulate erythropoiesis, but there is growing acceptance of the belief that a hormone, erythropoietin, provides the marrow with the immediate stimulus for blood production. In 1948, Berk, Burchenal, Wood, and Castle (1), and, in 1949, Schwartz and Stats (2) found that oxygenation of bone marrow was increased in states of marrow overactivity. Reissmann (1950) found increased hemopoiesis in the normal partner when 1 of a pair of parabiotic rats breathed a low oxygen gas mixture (3). Stohlman, Rath, and Rose (1954) found that in reverse patent ductus arteriosus the well-oxygenated sternal
GRANT JL, SMITH B. Bone Marrow Gas Tensions, Bone Marrow Blood Flow, and Erythropoiesis in Man. Ann Intern Med. ;58:801–809. doi: 10.7326/0003-4819-58-5-801
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Published: Ann Intern Med. 1963;58(5):801-809.
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