S. O. WAIFE, M.D., F.A.C.P.; C. J. JANSEN JR., M.D.; R. E. CRABTREE, PH.D.; E. L. GRINNAN, PH.D.; P. J. FOUTS, M.D., F.A.C.P.
Since the discovery of vitamin B12 as the essential hematopoietic factor deficient in patients with pernicious anemia in relapse, there have been a number of studies using crystalline cyanocobalamin, without intrinsic factor, in oral therapy. Doses of less than 30 micrograms a day generally have been unsuccessful (1). Suboptimal responses have been reported on doses of up to 100 micrograms a day (1, 2). Better results have followed administration of still larger amounts—as much as 1,000 micrograms a day (3). Other schedules have been used, for example, 1,000 micrograms (1 milligram) once a week (3-7). In Table 1, we have
S. O. WAIFE, C. J. JANSEN, R. E. CRABTREE, E. L. GRINNAN, P. J. FOUTS. Oral Vitamin B12 without Intrinsic Factor in the Treatment of Pernicious Anemia. Ann Intern Med. 1963;58:810–817. doi: 10.7326/0003-4819-58-5-810
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Published: Ann Intern Med. 1963;58(5):810-817.
Hematology/Oncology, Red Cell Disorders.
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