JOHN H. BLAND, M.D., F.A.C.P.; LESLIE CLARK, B.S., M.S.
Most of the information on the macroglobulin, rheumatoid factor, has been derived from studies on sera. Relatively few data are available on the presence of rheumatoid factor in connective tissue extracts or body fluids other than serum. Rheumatoid factors have most of the properties of antibodies; proteins of antibody type are very probably synthesized by cells of the lymphocyte-plasma cell series. Plasma cells only rarely are found circulating in the blood, and in the mammal they are connective tissue cells located in extravascular extracellular space; plasma cells are ubiquitous, and like lymphocytes from which they arise they are found in
BLAND JH, CLARK L. Rheumatoid Factor in Serum and Joint Fluid. Ann Intern Med. ;58:829–836. doi: 10.7326/0003-4819-58-5-829
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Published: Ann Intern Med. 1963;58(5):829-836.
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