FRANK O. BECKER, M.D.; PETER G. ECONOMOU, M.D.; THEODORE B. SCHWARTZ, M.D., F.A.C.P.
When the physician finds a patient with nodular goiter, he must consider the possibility of malignancy and decide whether surgery is indicated. Surgeons, generally, have found that the incidence of carcinoma in nodular goiter is high and recommend immediate surgery (1-5). Internists (6-8), on the other hand, conclude the incidence is low and in most instances suggest medical management.
With regard to solitary nodules, the advent of the scintogram has led to more agreement of opinion. This technique permits a qualitative distinction between hyperfunctioning ("hot") and hypofunctioning ("cold") nodules. Means (9), in 1950, stated: "So far we have never found
FRANK O. BECKER, PETER G. ECONOMOU, THEODORE B. SCHWARTZ. The Occurrence of Carcinoma in "Hot" Thyroid Nodules: Report of Two Cases. Ann Intern Med. 1963;58:877–882. doi: 10.7326/0003-4819-58-5-877
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Published: Ann Intern Med. 1963;58(5):877-882.
Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology, Thyroid Disorders.
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