DONALD W. MULDER, M.D.; R. K. WINKELMANN, M.D.; EDWARD H. LAMBERT, M.D.; G. ROY DIESSNER, M.D.; FRANK M. HOWARD JR., M.D.
Polymyositis and dermatomyositis cause weakness and atrophy (1, 2) of muscle. Eaton in a classic paper delineated the clinical syndrome of polymyositis and noted "that the muscular component in the clinical entity polymyositis and dermatomyositis is identical." Within weeks to months patients with this disorder develop a symmetric weakness most marked in the proximal muscles (3). In most patients the disease can be suspected on the basis of the patient's history and clinical examination, and the diagnosis can be corroborated by muscle biopsy, electromyographic findings, and studies of the enzymes in the blood.
The clinical course of polymyositis, unlike that
MULDER DW, WINKELMANN RK, LAMBERT EH, DIESSNER GR, HOWARD FM. Steroid Therapy in Patients with Polymyositis and Dermatomyositis. Ann Intern Med. ;58:969–976. doi: 10.7326/0003-4819-58-6-969
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Published: Ann Intern Med. 1963;58(6):969-976.
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