VICTOR HERBERT, M.D.; RALPH ZALUSKY, M.D.; CHARLES S. DAVIDSON, M.D., F.A.C.P.
Macrocytosis has been observed frequently in association with cirrhosis since 1884 (1). The concomitant presence of macrocytosis, anemia, and cirrhosis, usually in association with alcoholism, sometimes with a macronormoblastic or even a megaloblastic bone marrow, has been frequently noted in the medical literature (2-10).
In 1938, noting no correlation between macrocytosis and severity of liver damage, Bianco and Jolliffe (2) concluded: "In view of these findings we are inclined to regard the macrocytosis of the alcohol addict not as a manifestation of inability on the part of the liver to store a hematopoietic principle, but as an extrinsic deficiency of
HERBERT V, ZALUSKY R, DAVIDSON CS. Correlation of Folate Deficiency with Alcoholism and Associated Macrocytosis, Anemia, and Liver Disease. Ann Intern Med. 1963;58:977–988. doi: 10.7326/0003-4819-58-6-977
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Published: Ann Intern Med. 1963;58(6):977-988.
Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease, Red Cell Disorders, Tobacco, Alcohol, and Other Substance Abuse.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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