H. D. ITSKOVITZ, M.D.; E. A. HILDRETH, M.D., F.A.C.P.; A. M. SELLERS, M.D., F.A.C.P.; W. S. BLAKEMORE, M.D., F.A.C.S.
Recent studies relating renin and angiotensin to the regulation of aldosterone secretion have stimulated renewed interest in the juxtaglomerular cells of the kidney and in their role in normal body physiology and in human hypertension (1-5). The juxtaglomerular cells are located in the terminal portion of the renal afferent arteriole (6). They contain cytoplasmic granules which are believed to be renin or a precursor of renin (5, 7-9). Under normal circumstances, the human kidney has few juxtaglomerular granules and little renin activity (10). When the arterial blood flow to the kidney is sufficiently compromised, as demonstrated by Goldblatt (11), the
ITSKOVITZ HD, HILDRETH EA, SELLERS AM, BLAKEMORE WS. The Granularity of the Juxtaglomerular Cells in Human Hypertension: Histologic and Clinical Correlations. Ann Intern Med. ;59:8–23. doi: 10.7326/0003-4819-59-1-8
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Published: Ann Intern Med. 1963;59(1_Part_1):8-23.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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