JOSEPH B. KIRSNER, M.D., F.A.C.P.; JEAN A. SPENCER, M.D.
Despite the genetic heterogeneity of man, surveys of disease among population groups and families are important in the search for possible etiologic mechanisms in obscure diseases. Whereas ulcerative colitis and regional enteritis hitherto had been regarded as characteristically limited to one member of a family, recent observations suggest a more than casual family incidence of these diseases.
Spriggs (1) in 1934, noted ulcerative colitis in 2 brothers and a sister. Moltke (2) recorded 5 families with multiple instances of the disease (mother, daughter, 2; brother, sister, 2; and father, daughter, one). Jackman and Bargen (3) in 1942, described occurrences in
JOSEPH B. KIRSNER, JEAN A. SPENCER. Family Occurrences of Ulcerative Colitis, Regional Enteritis, and Ileocolitis. Ann Intern Med. 1963;59:133–144. doi: 10.7326/0003-4819-59-2-133
Download citation file:
Published: Ann Intern Med. 1963;59(2):133-144.
Gastroenterology/Hepatology, Inflammatory Bowel Disease.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use