JAMES R. BRAYSHAW, M.D.; FORREST HARRIS, M.D.; PAUL R. MCCURDY, M.D.
Since occult gastrointestinal bleeding is of paramount importance in the genesis of iron deficiency in the adult, the physician must know how oral therapy with iron salts affects the results of the commonly used tests for occult blood in the stool. Some investigators have suggested that oral iron can produce a weakly positive guaiac reaction (1, 2), but others have been unable to confirm these findings (3-6). Interpretation of these studies is difficult because there were relatively few determinations, the types and doses of oral iron varied, and the tests were not performed by one individual in standard fashion.
BRAYSHAW JR, HARRIS F, MCCURDY PR. The Effect of Oral Iron Therapy on the Stool Guaiac and Orthotolidine Reactions. Ann Intern Med. ;59:172–179. doi: 10.7326/0003-4819-59-2-172
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Published: Ann Intern Med. 1963;59(2):172-179.
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