D. JOSEPH DEMIS, PH.D., M.D.
Mastocytosis, an abnormal proliferation of tissue mast cells, is being recognized with increasing frequency as a systemic disease. This disorder was originally described by Nettleship in 1869 (1) as its cutaneous manifestation, urticaria pigmentosa. It was not until 1949 that Ellis (2) reported autopsy findings which conclusively demonstrated generalized systemic involvement with infiltration of skin, liver, spleen, bone marrow, lymph nodes, pancreas, and thymus. In the past decade, reports of symptoms associated with the typical clinical eruption have been steadily accumulating (3).
Over the past 4 years, 31 patients with mastocytosis have been evaluated. Of these, 12 were noted to
DEMIS DJ. The Mastocytosis Syndrome: Clinical and Biological Studies. Ann Intern Med. ;59:194–206. doi: 10.7326/0003-4819-59-2-194
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Published: Ann Intern Med. 1963;59(2):194-206.
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