DONALD C. HARRISON, M.D.; CHARLES A. CHIDSEY, M.D.; EUGENE BRAUNWALD, M.D., F.A.C.P.
The clinical effectiveness of metaraminol (Aramine), a widely used sympathomimetic agent, has been well documented (1-4). However, the mechanism of its action on the heart and circulatory system is not clear. Although its duration of action is longer, many of the hemodynamic effects of metaraminol are identical to those produced by the sympathetic neurotransmitter, norepinephrine (5, 6). Since it has been shown previously that a number of aromatic vasoactive amines act primarily by releasing endogenous norepinephrine stores (7-9), it was considered that metaraminol may have a similar mechanism of action. This was further suggested by the clinical observation that after
HARRISON DC, CHIDSEY CA, BRAUNWALD E. Studies on the Mechanism of Action of Metaraminol (Aramine). Ann Intern Med. 1963;59:297–305. doi: 10.7326/0003-4819-59-3-297
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Published: Ann Intern Med. 1963;59(3):297-305.
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