DAVID PRAGER, M.D.; CONSTANTINE L. HAMPERS, M.D.; DANIEL S. KUSHNER, M.D., F.A.C.P.
Hemoglobinemia and hemoglobinuria with associated acute renal insufficiency has been noted following blood transfusions (1, 2), crush injuries (3), the accidental infusion of distilled water (4), with malaria (5), following drug ingestion (5, 6, 7), with certain infections (8, 9), in paroxysmal nocturnal hemoglobinuria (10, 11), with thermal burns (12), and in paroxysmal cold hemoglobinuria (13).
Idiopathic or symptomatic acquired auto-immune hemolytic anemia with hemoglobinemia and hemoglobinuria is an unusual cause of acute renal failure. This is evidenced by our finding of only 5 case reports (14-18) in the literature. Two of the cases (14, 15) would be classified as
PRAGER D, HAMPERS CL, KUSHNER DS. Acquired Auto-Immune Hemolytic Anemia with Acute Renal Insufficiency. Ann Intern Med. ;59:357–363. doi: 10.7326/0003-4819-59-3-357
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Published: Ann Intern Med. 1963;59(3):357-363.
Acute Kidney Injury, Autoimmune Kidney Disease, Hematology/Oncology, Nephrology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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