A. P. DOYLE, M.D.; H. R. HELLSTROM, M.D.
More than 80 examples of lymphadenopathy occurring after anticonvulsant therapy have been recorded. Most of the hydantoin derivatives have been implicated as being responsible for this effect, mephenytoin, 3-methyl-5, 5-phenylethyl hydantoin (Mesantoin®) being the chief offender. In addition, fatal polyarteritis nodosa (1), aplastic anemia (2), and systemic lupus erythematosus (3) have been observed after anticonvulsant therapy.
The lymphadenopathy has a fairly characteristic clinical course that begins one week to several months after the offending drug therapy has been started. The involved nodes are often tender; they may be several centimeters in diameter and generally regress within a few weeks after
DOYLE AP, HELLSTROM HR. Mesantoin Lymphadenopathy Morphologically Simulating Hodgkin's Disease. Ann Intern Med. ;59:363–368. doi: 10.7326/0003-4819-59-3-363
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Published: Ann Intern Med. 1963;59(3):363-368.
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