MURRAY N. SILVERSTEIN, M.D.; PATRICK J. KELLY, M.D.
Leukemic involvement of bone and joints has been recognized from the time of Virchow (1). If bone and joint involvement predominates in acute leukemia when first seen, considerable diagnostic confusion may arise. In several reported cases, acute leukemia closely mimicked rheumatic fever (2-7). The purpose of this presentation is to review a group of cases of acute leukemia in which the clinical course was dominated by bone and joint symptoms.
From two 3-year periods taken at random (1945 to 1947 and 1955 to 1957), the records of all Mayo Clinic cases diagnosed as acute leukemia were reviewed.
SILVERSTEIN MN, KELLY PJ. Leukemia with Osteoarticular Symptoms and Signs. Ann Intern Med. ;59:637–645. doi: 10.7326/0003-4819-59-5-637
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Published: Ann Intern Med. 1963;59(5_Part_1):637-645.
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