WILLIAM MCFARLAND, M.D., F.A.C.P.; EUGENE P. LIBRE, M.D.
Hematologic abnormalities are well-recognized in cirrhosis of the liver and studies to elucidate the cause usually incriminate the advanced liver disease and secondary splenomegaly with resultant hypersplenism. Recently, however, studies have suggested that liver disease and hypersplenism may not be essential etiologic factors. In a group of alcoholic patients studied by Jandl (1), the hematologic findings in two patients led him to suspect a direct suppression of the bone marrow by alcohol. In a later report, McCurdy, Pierce, and Rath (2) have demonstrated vacuolization of erythrocyte precursors in the marrows of acute alcoholics similar to the changes observed in the
MCFARLAND W, LIBRE EP. Abnormal Leukocyte Response in Alcoholism. Ann Intern Med. 1963;59:865–877. doi: 10.7326/0003-4819-59-6-865
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Published: Ann Intern Med. 1963;59(6):865-877.
Prevention/Screening, Tobacco, Alcohol, and Other Substance Abuse.
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