ROBERT E. REISMAN, M.D.; CARL E. ARBESMAN, M.D., F.A.C.P.; NOEL R. ROSE, PH.D.
Potential anaphylactoid reactions to horse serum can generally be avoided by prior skin or conjunctival testing. Horse serum products, most frequently tetanus antitoxin, are usually withheld from positive reactors, or, if administered, done so very cautiously. Although serious reactions have occasionally occurred from intradermal testing itself, the immunological pathogenesis of such anaphylactoid reactions has not been thoroughly documented.
The following studies give some insight into the mechanisms involved, and also can be contrasted with the previously studied immunopathogenesis of primary serum disease (1-3).
J. R., a 20-year-old male college student, lacerated his left palm with a piece of
REISMAN RE, ARBESMAN CE, ROSE NR. Anaphylactoid Reaction Following an Intradermal Test of Tetanus Antitoxin. Ann Intern Med. ;59:883–886. doi: 10.7326/0003-4819-59-6-883
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Published: Ann Intern Med. 1963;59(6):883-886.
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